A Munchkins To Love Article:

Hypoglycemia  Low Blood Sugar and the Small Breed Dog

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What are some of the signs?

Loss of appetite
Shivering
Unusually quiet behavior
Unresponsiveness (get to a vet--this is dangerous at this point)

What is the remedy?
Nutri-Cal calorie food supplement)  It looks like brown toothpaste gel and you can get it at any good pet store.
honey
maple syrup
the vet in extreme cases
*Do not use any corn syrup based product as dogs can often be allergic to corn

Will this always be a problem?
Probably not.  Most puppies outgrow this problem.  This seems to be associated with very young age and very small size.  But it can in some instances be a
chronic problem.
It's a common problem with small breeds, especially the tiny ones in small breeds.  They have trouble maintaining their blood sugar.  This can be a puppy situation
(due to stress), but in some cases will carry over into adulthood.  It can be a very serious situation and an ounce of prevention is worth a pound of cure.

Is there anything I can do to prevent this?

Not exactly, but being watchful and aware of the signs can help you ward off a problem.
You can have the puppy free-feed (food out all the time).  This can slow housebreaking, but in a case like this, things need to go more slowly anyway. 
You can also offer small amounts of canned food, although this would not be part of a normal diet.  (Too much canned food is like too much candy under normal situations)